Efeitos da suplementação de vitamina D no lúpus eritematoso sistêmico: uma revisão da literatura

Abstract

The objective of this study was to investigate the effects of vitamin D supplementation on systemic lupus erythematosus (SLE). A literature review was carried out with articles in Portuguese and English, in the National Library of Medicine (PUBMED) and Virtual Health Library (VHL) databases, dated 2013 to 2023, available in full for free, and those with samples were excluded. animals and which were not clinical trials. The final sample was 3 articles that met the eligibility criteria, all with supplementation from 1400UI/day to 8000UI/day over a period of 6 to 12 months and evaluated the effects of vitamin D supplementation in SLE in relation to disease activity and its parameters, fatigue and bone mineral density (BMD). The results of this study show that supplementation and adequacy of serum vitamin D levels have significant effects on SLE, highlighting the improvement in disease activity, including anti-dsDNA negativity, improvement in the global fatigue classification and in specific indices, such as improving social life, improving bone mineral density scores, bringing risks of osteopenia and osteoporosis and better functioning of the immune system. However, there is no standardization of the appropriate dose and supplementation time to achieve such benefits, meaning that more studies on the subject are needed to ensure greater effectiveness in the treatment.

Keywords: Lupus. Supplementation. Vitamin D.