Efeitos da suplementação de curcumina em pacientes com doença hepática gordurosa associada a disfunção metabólica: revisando evidências científicas

Abstract

Objective: To identify the effects of curcumin supplementation in the treatment of fatty liver disease associated with metabolic dysfunction (MDHDHD). Methods: a narrative literature review was conducted using randomized clinical trials that aimed to evaluate the effects of this polyphenol on anthropometric and metabolic parameters related to this disease, published in Portuguese and English, in the last five years. Results: most studies observed that curcumin supplementation can reduce liver fat by altering metabolic parameters, such as decreasing the serum concentration of triglycerides and LDL-cholesterol, and increasing HDL-cholesterol, promoting improvement of NAFLD. Conclusion: curcumin supplementation may represent benefits due to the possible reduction of biochemical markers associated with liver dysfunction such as alanine transaminase (ALT) and aspartate transaminase (AST). Regarding its ability to reduce anthropometric parameters, such as body weight and waist circumference, it was not possible to evidence the influence of this polyphenol on these variables.