Efeito da suplementação de probióticos na ansiedade e depressão: uma revisão de literatura

Abstract

Objective: To evaluate the effect of probiotic supplementation on anxiety and depression. Method: This is a literature review conducted using the PubMed database, with articles searched up to February 2025. Randomized clinical trials involving probiotic supplementation in individuals diagnosed with anxiety and/or depression were included. Eligibility criteria, data extraction, and methodological assessment followed PRISMA guidelines. A total of 17 studies were analyzed, comprising 1,257 participants. Most interventions lasted 30 days or more, with emphasis on strains from the Lactobacillus and Bifidobacterium genera. Results: 82.4% of the studies reported a significant reduction in emotional symptoms, along with improvements in gut microbiota composition, sleep quality, and inflammatory markers. Conclusion: Probiotic supplementation shows positive effects as a complementary strategy in the management of anxiety and depression, with minimal adverse effects reported. However, further standardization regarding strains, dosages, and duration of use is still needed.