Tipo:	Trabalho de Conclusão de Curso
Título:	Clinical relevance of drug interactions in psychiatry: antidepressants and antipsychotics
Autor(es):	Espindola, Gustavo Modesto Carvalho, Maria Eugênia Ruas
Primeiro Orientador:	Silva, Vinicius Barreto da
metadata.dc.contributor.referee1:	Alves, Suzana Ferreira
Resumo:	OBJECTIVES: The study aims to analyze drug interactions between antidepressants and antipsychotics, with a focus on their potential adverse effects and clinical relevance. The objective is to provide criteria for minimizing avoidable harm and improving treatment outcomes. METHODS: The "Interactions Checker" module of Drugs.com was used to screen for interactions between 14 antidepressants and 11 antipsychotics. Data were collected based on two meta-analyses and interactions were evaluated for their mechanism, clinical outcomes, and management strategies. RESULTS: Interactions were categorized into cardiovascular effects (QT interval prolongation and orthostatic hypotension) and central nervous system (CNS) effects (CNS depression, parasympatholytic effects, risk of seizures, and akathisia). Antidepressants such as citalopram, escitalopram, venlafaxine, and paroxetine were associated with QT interval prolongation, while haloperidol, risperidone, and quetiapine were highlighted among antipsychotics. Orthostatic hypotension was notable with quetiapine, clozapine, tricyclic, and tetracyclic antidepressants. CNS effects included depression (SSRIs, ADT, Ziprasidone, Perphenazine), seizures (Bupropion, antipsychotics), akathisia (Pimozide, Paroxetine), and parasympatholytic effects (SSRIs, Ziprasidone, Haloperidol). CONCLUSION: This study provides a comprehensive analysis of drug interactions between antidepressants and antipsychotics, emphasizing their clinical implications. The findings offer guidance for healthcare professionals to ensure safer and more effective treatment approaches for patients with psychiatric disorders.
Palavras-chave:	Antidepressants Antipsychotics Drug interactions Pharmacology
CNPq:	CNPQ::CIENCIAS DA SAUDE
Idioma:	eng
País:	Brasil
Editor:	Pontifícia Universidade Católica de Goiás
Sigla da Instituição:	PUC Goiás
metadata.dc.publisher.department:	Escola de Ciências Médicas e da Vida
Tipo de Acesso:	Acesso Aberto
URI:	https://repositorio.pucgoias.edu.br/jspui/handle/123456789/5756
Data do documento:	18-Mai-2023
Aparece nas coleções:	TCC Medicina

Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.