PRODUÇÃO ACADÊMICA Repositório Acadêmico da Graduação (RAG) TCC Medicina
Use este identificador para citar ou linkar para este item: https://repositorio.pucgoias.edu.br/jspui/handle/123456789/5756
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Campo DCValorIdioma
dc.creatorEspindola, Gustavo Modestopt_BR
dc.creatorCarvalho, Maria Eugênia Ruaspt_BR
dc.date.accessioned2023-06-21T01:09:14Z-
dc.date.available2023-06-21T01:09:14Z-
dc.date.issued2023-05-18-
dc.identifier.urihttps://repositorio.pucgoias.edu.br/jspui/handle/123456789/5756-
dc.description.sponsorshipNão recebi financiamentopt_BR
dc.languageengpt_BR
dc.publisherPontifícia Universidade Católica de Goiáspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntidepressantspt_BR
dc.subjectAntipsychoticspt_BR
dc.subjectDrug interactionspt_BR
dc.subjectPharmacologypt_BR
dc.titleClinical relevance of drug interactions in psychiatry: antidepressants and antipsychoticspt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor1Silva, Vinicius Barreto dapt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7687272405825669pt_BR
dc.contributor.referee1Alves, Suzana Ferreirapt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/9799183444893510pt_BR
dc.description.resumoOBJECTIVES: The study aims to analyze drug interactions between antidepressants and antipsychotics, with a focus on their potential adverse effects and clinical relevance. The objective is to provide criteria for minimizing avoidable harm and improving treatment outcomes. METHODS: The "Interactions Checker" module of Drugs.com was used to screen for interactions between 14 antidepressants and 11 antipsychotics. Data were collected based on two meta-analyses and interactions were evaluated for their mechanism, clinical outcomes, and management strategies. RESULTS: Interactions were categorized into cardiovascular effects (QT interval prolongation and orthostatic hypotension) and central nervous system (CNS) effects (CNS depression, parasympatholytic effects, risk of seizures, and akathisia). Antidepressants such as citalopram, escitalopram, venlafaxine, and paroxetine were associated with QT interval prolongation, while haloperidol, risperidone, and quetiapine were highlighted among antipsychotics. Orthostatic hypotension was notable with quetiapine, clozapine, tricyclic, and tetracyclic antidepressants. CNS effects included depression (SSRIs, ADT, Ziprasidone, Perphenazine), seizures (Bupropion, antipsychotics), akathisia (Pimozide, Paroxetine), and parasympatholytic effects (SSRIs, Ziprasidone, Haloperidol). CONCLUSION: This study provides a comprehensive analysis of drug interactions between antidepressants and antipsychotics, emphasizing their clinical implications. The findings offer guidance for healthcare professionals to ensure safer and more effective treatment approaches for patients with psychiatric disorders.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEscola de Ciências Médicas e da Vidapt_BR
dc.publisher.initialsPUC Goiáspt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.degree.graduationMedicinapt_BR
dc.degree.levelGraduaçãopt_BR
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