Use este identificador para citar ou linkar para este item:
https://repositorio.pucgoias.edu.br/jspui/handle/123456789/4692
Tipo: | Trabalho de Conclusão de Curso |
Título: | Pharmacophoric modeling in the investigation of compounds with chemoprotective potential present in the species Mauritia flexuosa |
Título(s) alternativo(s): | Pharmacophoric modeling in the investigation of compounds with chemoprotective potential present in the species Mauritia flexuosa |
Autor(es): | Menezes, Isabel Cristina Borges de Camara, João Pedro Carrijo Cunha |
Primeiro Orientador: | Borges, Leonardo Luiz |
metadata.dc.contributor.referee1: | Ribeiro, Andrea Alves |
metadata.dc.contributor.referee2: | Teófilo, Monatha Nayara Guimarães |
Resumo: | The extract of Mauritia flexuosa, popularly known as “buriti” is rich in bioactive compounds and is characterized as a rich species with antioxidant, antimicrobial, antiplatelet, antitumor, and antilipemic activity. Our methods include using in silico tools to assess biological activities, dynamics, and toxicity prediction. We also performed pharmacophore modeling studies. We found phenolic compounds, flavonoids, carotenoids, fatty acids, and phytosterols. Five flavonoids have predicted chemoprotective activity and affinity for receptors and spatial alignment between the chemical marker present in the M. fleuxosa species and the five ligands with lower IC50 values capable of interacting with their respective targets. In silico pharmacophoric analyzes showed that the most promising structures present in the extract were kaempferol, quercetin, luteolin, apigenin, and caffeic acid, which presented structural alignments according to the analyses. This work opens perspectives to direct future studies in vitro and in vivo with the molecules found during the investigations. |
Palavras-chave: | Medicinal plants Arecaceae Flavonoids In silico |
CNPq: | CNPQ::CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS |
Idioma: | eng |
País: | Brasil |
Editor: | Pontifícia Universidade Católica de Goiás |
Sigla da Instituição: | PUC Goiás |
metadata.dc.publisher.department: | Escola de Ciências Médicas e da Vida |
Tipo de Acesso: | Acesso Aberto |
URI: | https://repositorio.pucgoias.edu.br/jspui/handle/123456789/4692 |
Data do documento: | 26-Mai-2022 |
Aparece nas coleções: | TCC Medicina |
Arquivos associados a este item:
Arquivo | Tamanho | Formato | |
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TCC INGLES 01.07.docx | 340,92 kB | Microsoft Word XML | Visualizar/Abrir |
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