PRODUÇÃO ACADÊMICA Repositório Acadêmico da Graduação (RAG) TCC Medicina
Use este identificador para citar ou linkar para este item: https://repositorio.pucgoias.edu.br/jspui/handle/123456789/4692
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Campo DCValorIdioma
dc.creatorMenezes, Isabel Cristina Borges dept_BR
dc.creatorCamara, João Pedro Carrijo Cunhapt_BR
dc.date.accessioned2022-07-01T16:46:11Z-
dc.date.available2022-07-01T16:46:11Z-
dc.date.issued2022-05-26-
dc.identifier.urihttps://repositorio.pucgoias.edu.br/jspui/handle/123456789/4692-
dc.languageengpt_BR
dc.publisherPontifícia Universidade Católica de Goiáspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMedicinal plantspt_BR
dc.subjectArecaceaept_BR
dc.subjectFlavonoidspt_BR
dc.subjectIn silicopt_BR
dc.titlePharmacophoric modeling in the investigation of compounds with chemoprotective potential present in the species Mauritia flexuosapt_BR
dc.title.alternativePharmacophoric modeling in the investigation of compounds with chemoprotective potential present in the species Mauritia flexuosapt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor1Borges, Leonardo Luizpt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/8153436057725516pt_BR
dc.contributor.referee1Ribeiro, Andrea Alves-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/2715321189940482pt_BR
dc.contributor.referee2Teófilo, Monatha Nayara Guimarães-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/8202836647237491pt_BR
dc.description.resumoThe extract of Mauritia flexuosa, popularly known as “buriti” is rich in bioactive compounds and is characterized as a rich species with antioxidant, antimicrobial, antiplatelet, antitumor, and antilipemic activity. Our methods include using in silico tools to assess biological activities, dynamics, and toxicity prediction. We also performed pharmacophore modeling studies. We found phenolic compounds, flavonoids, carotenoids, fatty acids, and phytosterols. Five flavonoids have predicted chemoprotective activity and affinity for receptors and spatial alignment between the chemical marker present in the M. fleuxosa species and the five ligands with lower IC50 values capable of interacting with their respective targets. In silico pharmacophoric analyzes showed that the most promising structures present in the extract were kaempferol, quercetin, luteolin, apigenin, and caffeic acid, which presented structural alignments according to the analyses. This work opens perspectives to direct future studies in vitro and in vivo with the molecules found during the investigations.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEscola de Ciências Médicas e da Vidapt_BR
dc.publisher.initialsPUC Goiáspt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOSpt_BR
dc.degree.graduationMedicinapt_BR
dc.degree.levelGraduaçãopt_BR
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