Análise dos polimorfismos RS10750097 e RS 3741298 dos genes da APOA5 região ZNF 259 e as suas influências nos quadros de dislipidemia

Abstract

Dyslipidemia is defined as a disturbance in lipid metabolism and appears due to external causes or predisposing genetic disorders. The present case-control study aimed to analyze the correlation between the genetic polymorphisms RS10750097 and RS3741298 associated with ApoA5-ZNF259 lipoprotein and the development of dyslipidemia. A sample of 200 military police officers from the state of Goiás was used and the genotyping of the polymorphisms was performed using the TaqMan Real Time PCR® kit (SNP Genotyping Kit, AppliedBiosystems, USA). From the participating individuals, 93% were male and 7% were female, the case group was composed of 115 participants who had na altered lipid profile and the control group 84 participants with a lipid profile within the reference values. The polymorphisms observed in the group of cases and controls showed a significant difference between the two groups for all the variables analyzed. However, When analyzing 95% of the Confidence Interval and the Odds Ratio, it was evidenced that the ratio of chance of a case presente changes in the variables total cholesterol, triglycerides, HDL, non-HDLand LDL by the presence of the polymorphisms RS10750097 and RS3741298 does not exist. In conclusion, the polymorphisms studied did not influence the development of dyslipidemias within the variables involved in this case-control study.