Evaluation of the effects of Spondias mombin extract

Abstract

Aim: analyze the effects of Spondias mombin extract Methods: Cell viability was evaluated by the MTT test. Fifteen Wistar rats were used, divided into 4 groups (control group – CT; control with extract – CT+EX; hyperlipidic diet – HL; hyperlipidic diet and extract HL+EX). For 12 weeks the animals were weighed and their blood glucose assessed. Afterwards, they were euthanized and the biological material was collected to evaluate the biochemical parameters and weighing the organs. Microbiological analyses showed the microbicidal action. Statistical analyses were performed by ANOVA, Two-way ANOVA, Brown-Forsythe, Bartlett’s ant T-test. Results: The evaluation of the animals confirmed the efficacy of the extract os Spondias mombin against the cell metabolism of rats, without negatively altering cell viability; the group of rats with a hyperlipidic diet showed an increase in body wight, however, in the individual assessment of the organs, there were no significant changes. The glycemic index, liver parameters, lipids, and mineral ions did not show significant chamges. Furthermore, the antimicrobial potencial of Spondias mombin extract was evidenced in relation to Staphylococcus aureus ATCC 29213 and Staphylococcus aureus BLACC. Conclusion: The results show that Spondias mombin extract does not interfere with cell viability and did not show cytotoxicity to the cells to which they were exposed, nor did it interfere with the metabolism, organs and biochemical indices of rats with a normal or hyperlipidic diet. With the microbicide potential observed, research can be carried out in order to obtain new drugs with antimicrobial action, and possible beneficial action to the cardiovascular system.