O uso de isoflavonas no controle dos sintomas do climatério: uma revisão da literatura

Abstract

This study reviews the use of isoflavones in managing menopausal symptoms, considering their application as a non-hormonal alternative for women with restrictions or a preference for complementary approaches. Objective: To evaluate the efficacy of isoflavones in managing menopausal symptoms. Methods: An integrative review with a qualitative approach was conducted, encompassing publications between 2015 and 2025 in three languages: Portuguese, English, and Spanish. Studies using animal models, reviews, and works without full text were excluded. Results: Thirteen studies involving soy-based products and formulations with red clover were included. Heterogeneity of results was observed, with some trials showing a reduction in hot flashes and night sweats and a punctual improvement in metabolic markers, while others did not show superiority compared to placebo. Effects on bone mineral density were limited in shorter follow-ups. Differences in formulation, dose, duration of use, and bioavailability, including individual equol production, influenced the clinical response. Conclusion: Isoflavones showed partial efficacy in controlling menopausal symptoms, with a better response for vasomotor symptoms, mainly hot flashes and night sweats. However, the results were not uniform across studies; the doses described varied between protocols, including 70 mg daily and 40 mg twice daily, with treatment durations ranging from 12 weeks to 24 months. Thus, isoflavones can be considered a possible non-hormonal alternative, provided that their use is individualized and considers formulation, dose, treatment duration, and intestinal metabolism.