Avaliação da atividade mutagênica de infinity12 pelo teste de mutagenicidade de ames em salmonella typhimurium

Abstract

Introduction. The widespread use of compounds marketed as “natural,” often promoted without consistent scientific evidence of efficacy, purity, and safety, highlights the importance of toxicological and mutagenic evaluation of these substances.Objective. The present study aimed to evaluate the mutagenic activity of a commercially available “natural” compound called Infinity12 at different concentrations, using the Ames mutagenicity test in Salmonella Typhimurium. Methodology. Four different concentrations of Infinity12 (1, 10, 50, and 100 mg/mL) were tested using the Ames test in Salmonella Typhimurium strain TA100. Results and Discussion. The results showed that the Infinity12 compound, at the tested concentrations, did not present mutagenic activity. None of the evaluated concentrations caused a significant increase in the number of revertant colonies compared to the negative control, and all presented a mutagenicity ratio (MR) lower than 2. Thus, under the experimental conditions tested, Infinity12 did not demonstrate mutagenic potential. However, studies emphasize that products marketed as “natural” are not necessarily safe, as they may contain substances such as paracetamol, piroxicam, and other components with potential toxic or genotoxic effects. Therefore, further studies are necessary to assess the long-term safety of the compound. Conclusion. These findings reinforce the need for strict regulatory monitoring of substances marketed as natural, aiming to protect public health against potentially harmful biological effects that are still not fully understood.