Análise da atuação do óleo de cannabis (full spectrum) na sensibilidade bacteriana

Abstract

Bacterial resistance represents a significant public health challenge, with an increasing number of bacteria exhibiting resistance to antimicrobials. Consequently, the search for novel antimicrobials has become progressively important. Cannabis is a plant of particular interest in this research area, as its cannabinoids contain a phenolic ring in their chemical structure, which may facilitate antimicrobial activity. In our study, we tested strains of Proteus mirabilis, Klebsiella pneumoniae Carbapenemase, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using full-spectrum cannabis oil containing 3% THC + CBD (900 mg) by means of the Kirby-Bauer technique with adapted diffusion. Our results indicated promising outcomes specifically for the Pseudomonas aeruginosa strain, which exhibited a 20 mm zone of inhibition, while the other strains did not demonstrate any sensitization. The observed sensitization of Pseudomonas aeruginosa could be attributed to several factors, such as the chemical structures of CBD and CBG. Both cannabinoids possess phenolic rings that potentially bind to lipopolysaccharides, thereby enhancing the permeability of the bacterial membrane. Furthermore, our study may provide a foundation for future investigations into the synergistic and antagonistic interactions between cannabinoids and conventional antibiotics.