Papel do Resveratrol na prevenção e na progressão da doença de Alzheimer

Abstract

Alzheimer’s disease is the most common cause of dementia in the elderly population, but there is no definitive treatment that leads to cure and health care today focused on prevention and improving the quality of life of the patient when the disease is already installed. The formation of amyloid beta plaques has been widely related to the disease becoming the target of studies for guidelines in the search for prevention and treatment of Alzheimer’s disease. Knowing that eating practice associated with lifestyle can be a factor that slows the onset and progression of Alzheimer’s disease, this work seeks evidence on the action of resveratrol in its prevention and progression. This is a literature review in the electronic databases Medline, Scielo, PubMed and Lilacs using the descriptors Alzheimer’s disease, resveratrol and dementia. After the search process and application of the inclusion and exclusion criteria, 10 articles were selected that focused on the antioxidant capacity of the bioactive compound, its tolerance and the ability to improve cognitive function. In this work it was possible to verify that resveratrol has important neuroprotective and antioxidant action reducing the action of reactive oxygen species in the process of formation of beta amyloid plaques, as it was possible to identify evidence on the tolerability of resveratrol supplementation, however results on the improvement of cognitive function were inconclusive, requiring further studies on the subject.