Aplicação da técnica de edição genômica CRISPR-CAS9 em doenças cardiovasculares: revisão bibliográfica

Abstract

Cardiovascular diseases stand out for being one of the most prevalent diseases in the population. The cause for its development is variable and may be due to genetics, lifestyle habits and multifactorial. CRISPR originally discovered in bacteria of the Escherischia coli species, is a mechanism of immunological adaptation. CRISPR-Cas9 could be a measure adopted to treat these genetic diseases. CRISPR-Cas9 is an alternative method, seeking to understand the origin, being used as an alternative route of treatment, especially in patients who do not adapt to conventional methods such as medications. A bibliographical review was carried out based on the platforms Pubmed, Scielo, Google Scholar, Periódico CAPES and books, with the aim of presenting the benefits that the CRISP-Cas9 technique can bring to the medicinal field, seeking a new treatment method mainly for heart disease with a focus on coronary artery disease. The study was promising in terms of its use in experiments, demonstrating results that could enable a new treatment.