MicroRNAs como biomarcadores de prognóstico no câncer de pâncreas: revisão sistemática

Abstract

Introduction: Pancreatic cancer is one of the most aggressive cancers, with an unfavorable prognosis and high metastasis rates. Given the pattern of the disease, it is important to develop measures for an early diagnosis. MicroRNAs are small RNA molecules that are important in the initial formation of tumor patterns and disease progression, thus being proposed as coherent biomarkers for the prognostic follow-up of these patients. Objective: To analyze the use of microRNAs for monitoring the prognosis of patients with pancreatic cancer, highlighting those involved in favorable or unfavorable prognoses and highlighting the most relevant ones. Methods: This is a systematic review of the literature, with a search for scientific articles in the PubMed database, using the descriptors: "pancreatic cancer" and "microRNA", which met the criteria for analysis of microRNAs in the prognosis of pancreatic cancer. pancreas. Results: A total of 18 articles were identified on the prognostic value of recognized microRNAs in the context of pancreatic cancer. A summary of the main points addressed in the articles was provided, about favorable and unfavorable prognoses. Thus, 7 articles mentioned favorable prognosis and 11 indicated unfavorable prognosis for the future of patients. The 20 microRNAs found in the research and their prognostic characteristics were mentioned, in which 15 were tabulated for worse disease evolution and 5 for higher survival rates. Conclusion: The microRNAs obtained in this study showed great potential for use as prognostic markers in pancreatic cancer. The identification of microRNAs in the context of pancreatic cancer is a good efficient investigation strategy in the future of oncology medicine.