Interações medicamentosas clinicamente relevantes do fármaco Clonazepam

Abstract

The use of benzodiazepines has been very common in the reality in which we live and is one of the least converted subjects in pharmacology, being extremely important for the clinical practice of each patient. The objective is to report the clinical repercussions of the clinically relevant drug interactions of the drug clonazepam. The present work is a review about the use of benzodiazepines, with particular emphasis on the properties of clonazepam, its excessive use and the contributions of the pharmacist for the rational use. It was carried out through data collection between 2021 and 2022, using as descriptors: clonazepam, abuse and dependence, and pharmaceutical regulation in Public Medline (PUBMED) and Google Scholar. The use of several drugs in the therapeutic strategy contributes to the beneficial effects of the treatment of endocrine diseases, such as: hypertension and diabetes, but can cause harmful effects in the association of the use of benzodiazepine drugs, such as the risk of a possible drug interaction. This work will be a cross-sectional study with information on drug interactions of clonazepam, identifying potentially dangerous combinations of the drug, highlighting the importance of understanding the interactions of clonazepam with other drugs. Through this study, it was possible to verify that the problems caused by the long-term use of BDZs can result in user dependence (chemical, physical or psychological), in addition to social and economic impacts.