Interações medicamentosas e reações adversas a hipoglicemiantes na população idosa do município de Goiânia – Goiás

Abstract

With the growing number of elderly people, it is possible to observe an increase in non-communicable chronic diseases and polypharmacy, favoring non-compliance with prescriptions, resulting in problems related to drug safety, drug interactions and adverse drug reactions. Thus, it is necessary to plan and organize Pharmaceutical Assistance in the primary care of the municipality and indispensable for the Rational Use of Medicines in the context of the unified health system. in elderly people in the municipality of Goiânia- Goiás. An integrative literature review was carried out with the objective of knowing the hypoglycemic agents available in the Municipal List of Essential Medicines in the municipality of Goiânia - Goiás. levels of care, considering the necessary articulation and observance of regional priorities defined in the decentralization of actions, with definition of the responsibilities of the different management instances. Negative drug interactions can lead to toxicity, change in drug absorption, change in gastrointestinal pH, competition for binding to plasma proteins, and change in biliary excretion and the enterohepatic cycle. Hypoglycemia forms an adverse drug reaction as a contributor to hospitalizations in the elderly. , on the other hand, detected a significant frequency of hyperglycemia induced by systemic corticosteroids. However, the vast majority of adverse reactions, especially in the elderly, correspond to type A related to the pharmacological properties of drugs and, precisely because of this, they are considered predictable and, therefore, preventable. With the growing number of elderly people in Brazil and in the world, chronic non-communicable diseases, natural from the aging process, are being considered a collective health problem as they can aggravate and/or promote the occurrence of other diseases, which leads to the use of several drugs favoring polypharmacy and non-compliance with prescriptions, resulting in problems related to drug safety.