Protótipos moleculares de origem vegetal descobertos e isolados no Brasil

Abstract

For long periods the therapeutic resources were predominantly made up of plants and plant extracts that are a source of active ingredients with pharmacological and biological effects. Medicinal plants have made a strong contribution for the development of new therapeutic strategies by means of their secondary metabolites. They arose from plant interaction with the environment and have their role in protecting against external agents and attracting pollinators. This work had the objective of conducting a bibliographical review on molecules of plant origin that have the potential to be molecular models for future new drugs. The search was conducted in the official databases on Portuguese articles with a publication interval between 2012 and 2022. According to the articles found, it was possible to identify several molecules, such as the lignan arctiine, pinocembrin, and quercetin, which have numerous biological activities. Metabolomics, a collection of quantitative and qualitative information about any secondary metabolites in a biological matrix, is used to analyze biodiverse actives. In addition to their structural variety, natural elements are considered to be important databases of potentially therapeutic bioactive substances and have a specific biological selectivity based on mechanisms of action that have been studied for their pharmacological properties for more than 500 years.