Tratamentos para psoríase e resultados clínicos: uma revisão integrativa

Abstract

Psoriasis is a non-contagious, chronic inflammatory disease that significantly impacts quality of life, requiring individualized treatment based on the severity of the condition. This study aimed to gather the main treatments for psoriasis, highlighting their mechanism of action, efficacy, and safety. The methodology employed in the construction of this article was an integrative literature review on the main psoriasis treatments and their clinical outcomes, searching the PubMed and Virtual Health Library (VHL) databases. A total of 20 articles published between 2016 and 2026 were selected. Based on the results obtained, four main treatment pillars for psoriasis were identified: topical treatments, phototherapy, systemic treatments, and complementary care and lifestyle. In mild-to-moderate cases, topical therapies remain the first line of treatment, with emphasis on the combination of calcipotriol and betamethasone dipropionate, which shows greater efficacy and a faster response than monotherapies. Additionally, new non-steroidal drugs, such as tapinarof and roflumilast, show promise, although they are still limited by high costs. In moderate-to-severe cases, phototherapy, systemic treatments, and biologic therapies play a central role, with the latter being highly effective in achieving clinical improvement. Concurrently, innovative approaches, such as the use of stem cells, are still under development. Finally, complementary care and lifestyle changes, combined with treatment adherence, are fundamental for controlling the disease and improving patients' quality of life. Thus, the integration of different therapeutic approaches, combined with complementary care and proper treatment adherence, is essential to optimize clinical outcomes and promote the improvement of patients' quality of life.