Gene ATM e os efeitos colaterais tardios da radioterapia em pacientes portadoras de câncer de colo de útero

Abstract

Cervical cancer has a high prevalence in Brazil and other developing countries. Patients with locally advanced cervical tumors undergo radiotherapy with a good response rate. The biggest challenge to be faced is the occurrence of late side effects. As the treatment of these adverse events is often ineffective, the best approach would be prevention with reduced doses for radiosensitive patients or contraindication of treatment in more extreme cases. For this possibility, however, it is still necessary to demonstrate the clinical or genetic profile of patients who may present serious late side effects after radiotherapy.