Relação entre uso de cannabis e alterações centrais e endócrinas : uma revisão integrativa de literatura

Abstract

Cannabis compounds act through endogenous receptors, CB1 and CB2, which are distributed throughout the body. CB1 is located mainly in the brain and has an inhibitory effect on neurotransmitters such as GABA and glutamate, but its main effect is on dopamine, generating a feeling of reward. CB2, on the other hand, is mainly in peripheral organs with an immunological function. Stress can interfere with mental health, affecting cognition, learning, causing anxiety disorders, obesity and depression. In addition, stress can affect quality of life, increasing absenteeism from work and negatively impacting economic productivity. The study was carried out as a narrative literature review, searched from August 2022 to January 2023 with the following keywords in English: Cannabis sp, THC, CBD, neuroendocrine pathways, stress. The search resulted in 34 articles, of which 6 were selected. In view of this, there is a need to develop research into understanding neuroendocrine mechanisms that could pave the way for new therapeutic approaches in the management of stress and related conditions.