PRODUÇÃO ACADÊMICA Repositório Acadêmico da Graduação (RAG) TCC Medicina
Use este identificador para citar ou linkar para este item: https://repositorio.pucgoias.edu.br/jspui/handle/123456789/6741
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Campo DCValorIdioma
dc.creatorCanzi, Camila Cássiapt_BR
dc.creatorPrado Júnior, Edivalde Ribeiro do-
dc.date.accessioned2023-12-17T13:49:59Z-
dc.date.available2023-12-17T13:49:59Z-
dc.date.issued2023-06-17-
dc.identifier.urihttps://repositorio.pucgoias.edu.br/jspui/handle/123456789/6741-
dc.description.sponsorshipNão recebi financiamentopt_BR
dc.languageengpt_BR
dc.publisherPontifícia Universidade Católica de Goiáspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHypertrophic cardiomyopathypt_BR
dc.subjectPercutaneous intramyocardial septal radiofrequency ablationpt_BR
dc.titleRadiofrequency ablation in patients with obstructive hypertrophic cardiomyopathy: A systematic review and meta-analysispt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor1Menezes Junior, Antônio da Silvapt_BR
dc.contributor.advisor1IDhttps://orcid.org/0000-0003-1751-5206pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/4141970817482471pt_BR
dc.contributor.referee1Resende, Aline Lázarapt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/0437379814315427pt_BR
dc.contributor.referee2Santos, Luciana da Ressurreiçãopt_BR
dc.description.resumoStudy objective Hypertrophic cardiomyopathy (HCM) is a genetic disease that can cause left ventricular outflow tract (LVOT) obstruction. This study analyzed the efficacy of radiofrequency ablation (RA) in improving clinical and hemodynamic factors in patients receiving obstructive HCM refractory treatment. This evaluation was necessary because of the small number of studies on the effectiveness of this technique for obstructive HCM in the existing literature. Design We used the PubMed, Embase, and Science Direct databases to identify randomized clinical trials and observational studies addressing the clinical and hemodynamic outcomes before and after RA in patients with HCM. Participants We selected six articles published between 2011 and 2022, comprising 304 patients (mean age: 45 years). Interventions We performed a bias assessment using the ROBINS I tool, and meta-analysis processing was performed using the STATA program (v.16.0). Results The left ventricular outflow tract (LVOT) gradient at rest and with stimulation decreased by 58.78 mmHg (p = 0.001) and 70.38 mmHg (total effect Z = 21.62; p < 0.0001), respectively. Additionally, the New York Heart Association (NYHA) functional class decreased by 0.43 (p = 0.001), indicating symptomatic and hemodynamic improvements. Furthermore, we observed a significant reduction in septal thickness (by 4 mm; p = 0.001). Conclusions RA improved the NYHA functional class and LVOT gradient at rest and with stimulation and reduced septal thickness. These results suggest that RA is effective in patients refractory to pharmacological therapy and unsuitable for alcohol septal ablation or myectomy. However, more studies, including randomized clinical trials, should be conducted to define the role of RA in interventional therapies.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEscola de Ciências Médicas e da Vidapt_BR
dc.publisher.initialsPUC Goiáspt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.degree.graduationMedicinapt_BR
dc.degree.levelGraduaçãopt_BR
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