O uso de canabinóides no tratamento da doença Parkinson: revisão sistemática da literatura

Abstract

Cannabis has been used in the treatment of several diseases as well as recreationally throughout time. On the other hand, the current scenario shows the growth of research on the use of this plant in the treatment of Parkinson's disease (PD). The present study aimed to conduct a systematic review on the use of Cannabis sp derivatives in the treatment of PD. The methodological path followed was a descriptive theoretical bibliographic survey of Cannabis, its effect on the body, definition of PD and the use of Cannabis in PD and presentation of a table gathering the studies found on Cannabis and PD, through the PRISMA tool (Systematic Reviews and Meta-Analyses). The results obtained were: a total of 205 studies were found that, after filtering by PRISMA, 19 articles were analyzed, with humans, animals and body cells in which 17 presented positive effects and two negative effects. Among the positive findings are: pain reduction, improved motor skills, fatigue reduction, and cognitive attenuation. Among the negative findings were: no improvement in pain level and sleep disturbance. It is important to note that the dosages, the means of admission and the stages in which the subject is against in PD are varied. It is concluded that ∆-9-tetrahydrocannabinol (THC) causes relaxing, euphorizing, analgesic and anti-inflammatory effects and cannabidiol (CBD) causes analgesic, anti-inflammatory, antispasmodic, antioxidant, antipsychotic and anxiolytic effects, making both cannabinoids indeed help in the improvement of several PD symptoms.