PRODUÇÃO ACADÊMICA Repositório Acadêmico da Graduação (RAG) TCC Medicina
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dc.creatorAlbernaz, Andréa Araújo dos Santos-
dc.creatorAlves, Deyse Maria Rodrigues-
dc.date.accessioned2021-06-21T23:51:55Z-
dc.date.available2021-06-21T23:51:55Z-
dc.date.issued2021-05-05-
dc.identifier.urihttps://repositorio.pucgoias.edu.br/jspui/handle/123456789/1875-
dc.description.abstractObjective: To identify chromosomal abnormalities associated with miscarriage in the first trimester of pregnancy through a systematic review of studies published worldwide. Methodology: This is a systematic review of the literature, of publications around the world, about the chromosomal abnormalities that are causes of miscarriage, in the first trimester of pregnancy, in the last 20 years. Results: This study included 17 articles, with a total sample of 10,951 abortion products analyzed. Of these, 5,083 (46.5%) had normal karyotype and, in 5,868 products of conception, chromosomal anomalies were identified, representing 53.5%. Aneuploidies were the most frequent alterations and there was a predominance of trisomies, which accounted for 62.1% of chromosome disorders, followed by polyploidies (12.7%) and X chromosome monosomy (12.2%). Other changes were also identified, but less frequently. Regarding maternal age, about 61.6% of the changes occurred in mothers aged 35 years or over. Conclusion: Chromosomal anomalies have an important impact on pregnancy losses. Therefore, the analysis of the product of conception is of fundamental importance to clarify the cause of abortion.pt_BR
dc.description.sponsorshipNão recebi financiamentopt_BR
dc.languageporpt_BR
dc.publisherPontifícia Universidade Católica de Goiáspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAneuploidiaspt_BR
dc.subjectAneuploidiaspt_BR
dc.subjectAberrações cromossômicaspt_BR
dc.subjectChromosome aberrationspt_BR
dc.subjectAborto espontâneopt_BR
dc.subjectSpontaneous abortionpt_BR
dc.subjectPrimeiro trimestre da gravidezpt_BR
dc.subjectPregnancy trimester firstpt_BR
dc.subjectCitogenéticapt_BR
dc.subjectCytogeneticspt_BR
dc.titleAlterações cromossômicas como causa de aborto espontâneo no primeiro trimestre de gestação: revisão sistemáticapt_BR
dc.title.alternativeChromosomal alterations as a cause of miscarriage in the first trimester of pregnancy: systematic reviewpt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor1Silva, Antonio Márcio Teodoro Cordeiro-
dc.contributor.advisor1IDhttps://orcid.org/0000-0003-0645-3599pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/4256300529988960pt_BR
dc.contributor.referee1Ataídes, Fábio Silvestre-
dc.contributor.referee1IDhttps://orcid.org/0000-0003-4614-5785pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/9523959031041843pt_BR
dc.contributor.referee2Oliveira, Marcus Vinícius Paiva de-
dc.contributor.referee2IDhttps://orcid.org/0000-0003-4355-0064pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/1672599081652980pt_BR
dc.description.resumoObjetivo: Identificar as anormalidades cromossômicas associadas ao abortamento espontâneo, no primeiro trimestre de gestação, por meio de revisão sistemática de estudos publicados em todo o mundo. Metodologia: Trata-se de revisão sistemática da literatura, de publicações em todo o mundo, acerca das anormalidades cromossômicas que são causas de aborto espontâneo, no primeiro trimestre de gestação, dos últimos 20 anos. Resultados: Fizeram parte deste estudo, 17 artigos, com amostra total de 10.951 produtos de abortos analisados. Destes, 5.083 (46,5%) tiveram cariótipo normal e, em 5.868 produtos de concepção, foram identificadas anomalias cromossômicas, representando 53,5%. As aneuploidias foram as alterações mais frequentes e houve predominância de trissomias, que representaram 62,1% das cromossomopatias, seguidas pelas poliploidias (12,7%) e monossomia do cromossomo X (12,2%). Outras alterações também foram identificadas, porém em menor frequência. Em relação à idade materna, cerca de 61,6% das alterações ocorreram em mães com idade superior ou igual a 35 anos. Conclusão: As anomalias cromossômicas têm importante impacto nas perdas gestacionais. Portanto, a análise do produto de concepção é de fundamental importância para o esclarecimento da causa do aborto.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEscola de Ciências Médicas, Farmacêuticas e Biomédicaspt_BR
dc.publisher.initialsPUC Goiáspt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::MEDICINApt_BR
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Journal Of Assisted Reproduction And Genetics. 2017; 35(2):265-271. http://dx.doi.org/10.1007/s10815-017-1069-1 29 Gug C, Rațiu A, Navolan D, Drăgan I, Groza IM, Păpurică M, Vaida MA, Mozoș I, Jurcă MC. Incidence and Spectrum of Chromosome Abnormalities in Miscarriage Samples: a retrospective study of 330 cases. Cytogenetic And Genome Research. 2019;158(4):171-183. http://dx.doi.org/10.1159/000502304 30 Ozawa N, Ogawa K, Sasaki A, Mitsui M, Wada S, Sago H. Maternal age, history of miscarriage, and embryonic/fetal size are associated with cytogenetic results of spontaneous early miscarriages. Journal Of Assisted Reproduction And Genetics. 2019;36(4):749-757. http://dx.doi.org/10.1007/s10815-019-01415-y 31 Waterman CA, Batstone P, Bown N, Cresswell L, Delmege C, English CJ, Fews G, Grimsley L, Imrie S , Kulkarni A, Mann K, Johnson R , Morgan SM, Roberts P, Simonic I, Trueman S, Wall M, McMullan D. The clinical utility of genetic testing of tissues from pregnancy losses. BJOG 2018; 125: 867– 873. 32 MIKWAR, Myy; MACFARLANE, Amanda J.; MARCHETTI, Francesco. Mechanisms of oocyte aneuploidy associated with advanced maternal age. Mutation Research/Reviews In Mutation Research 2020; 785:108320. http://dx.doi.org/10.1016/j .mrrev.2020.108320pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/4430010412718641pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/7556641005277948pt_BR
dc.degree.graduationMedicinapt_BR
dc.degree.levelGraduaçãopt_BR
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