https://repositorio.pucgoias.edu.br/jspui/handle/123456789/3 Inclui trabalhos de conclusão de cursos de graduação produzidos na PUC Goiás. Wed, 23 Sep 2026 09:56:04 GMT 2026-09-23T09:56:04Z https://repositorio.pucgoias.edu.br/jspui/handle/123456789/11169 Título: Configuração de serviço acadêmico no sistema Lyceum: uma abordagem para a modernização da gestão educacional Tipo: Trabalho de Conclusão de Curso Mon, 08 Jun 2026 00:00:00 GMT https://repositorio.pucgoias.edu.br/jspui/handle/123456789/11169 2026-06-08T00:00:00Z https://repositorio.pucgoias.edu.br/jspui/handle/123456789/11168 Título: Um estudo de centro em grafos Tipo: Trabalho de Conclusão de Curso Thu, 11 Jun 2026 00:00:00 GMT https://repositorio.pucgoias.edu.br/jspui/handle/123456789/11168 2026-06-11T00:00:00Z https://repositorio.pucgoias.edu.br/jspui/handle/123456789/11167 Título: Entre a virilidade e a vulnerabilidade: masculinidade hegemônica e sofrimento psíquico na literatura científica Tipo: Trabalho de Conclusão de Curso Wed, 10 Jun 2026 00:00:00 GMT https://repositorio.pucgoias.edu.br/jspui/handle/123456789/11167 2026-06-10T00:00:00Z https://repositorio.pucgoias.edu.br/jspui/handle/123456789/11166 Título: Avaliação das atividades citotóxica e genetóxica do peumus boldus utilizando como modelo experimental o teste allkium cepa Abstract: Peumus boldus Molina (boldo), commonly known as Chilean boldo, is a medicinal plant widely used in traditional medicine, particularly for its digestive and hepatoprotective properties. Despite its traditional use, toxicological safety assessment is essential to support the rational consumption of herbal preparations. This study aimed to evaluate the potential cytotoxic and genotoxic effects of an aqueous infusion of Peumus boldus using the Allium cepa bioassay as an experimental model. Allium cepa bulbs were initially germinated in distilled water and subsequently exposed to Chilean boldo infusion at concentrations of 2.5 and 5.0 mg/dL, with distilled water used as the negative control and colchicine as the positive control. After the experimental period, the roots were collected, fixed, stained with 2% acetic orcein, and analyzed by optical microscopy. Mitotic index, cell-cycle phases, chromosomal aberrations, and nuclear abnormalities were evaluated. The negative control showed a mean mitotic index of 14.82%, whereas the groups treated with 2.5 and 5.0 mg/dL showed mitotic indices of 11.4% and 12.66%, respectively, exhibiting a biological response similar to that of the negative control. In contrast, the positive control showed marked mitotic arrest. No relevant increase in chromosomal aberrations or nuclear abnormalities was observed in the groups treated with the plant infusion. Statistical analysis demonstrated a significant difference among the experimental groups, mainly attributable to the response of the positive control. Under the experimental conditions evaluated, the aqueous infusion of Peumus boldus at concentrations of 2.5 and 5.0 mg/dL showed low cytotoxicity and no significant evidence of genotoxic activity in the Allium cepa model. Further studies using different concentrations and experimental models are recommended to provide a more comprehensive characterization of its toxicological safety. Tipo: Trabalho de Conclusão de Curso Wed, 27 May 2026 00:00:00 GMT https://repositorio.pucgoias.edu.br/jspui/handle/123456789/11166 2026-05-27T00:00:00Z